Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses

Purpose: TRPM2 is a Ca2+-permeable channel that is activated by H2O2. TRPM2-mediated Ca2+ signaling has been implicated in the aggravation of inflammatory diseases. Therefore, the development of TRPM2 inhibitors to prevent the aggravation of these diseases is expected. We recently reported that some...

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Auteurs principaux: Shinichiro Yamamoto (Auteur), Takahiro Toda (Auteur), Ryo Yonezawa (Auteur), Takaharu Negoro (Auteur), Shunichi Shimizu (Auteur)
Format: Livre
Publié: Elsevier, 2017-05-01T00:00:00Z.
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