Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

• প্রধান লেখক: Takashi Maejima (লেখক), Tomohiro Sugano (লেখক), Hiroyuki Yamazaki (লেখক), Yasunobu Yoshinaka (লেখক), Takeshi Doi (লেখক), Sohei Tanabe (লেখক), Tomoko Nishimaki-Mogami (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2011-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, increase ABCA1 mRNA levels in hepatoma cell lines, bu...