Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

• Váldodahkkit: Takashi Maejima (Dahkki), Tomohiro Sugano (Dahkki), Hiroyuki Yamazaki (Dahkki), Yasunobu Yoshinaka (Dahkki), Takeshi Doi (Dahkki), Sohei Tanabe (Dahkki), Tomoko Nishimaki-Mogami (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2011-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Abstract.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, increase ABCA1 mRNA levels in hepatoma cell lines, bu...