Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

• Asıl Yazarlar: Takashi Maejima (Yazar), Tomohiro Sugano (Yazar), Hiroyuki Yamazaki (Yazar), Yasunobu Yoshinaka (Yazar), Takeshi Doi (Yazar), Sohei Tanabe (Yazar), Tomoko Nishimaki-Mogami (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2011-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, increase ABCA1 mRNA levels in hepatoma cell lines, bu...