Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells

Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells

Aims. Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) have become a promising tool in cardiovascular safety pharmacology. Immaturity of iPS-CMs remains an ongoing concern. We compared electrophysiological and contractile features of cardiac bodies (hiPS-CBs) derived from human-induced...

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Main Authors: Jan Trieschmann (Author), Moritz Haustein (Author), Annette Köster (Author), Jürgen Hescheler (Author), Konrad Brockmeier (Author), Gerardus Bennink (Author), Tobias Hannes (Author)
Format: Book
Published: Hindawi Limited, 2019-01-01T00:00:00Z.
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3rd Floor Main Library

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