Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells

• Glavni autori: Jan Trieschmann (Autor), Moritz Haustein (Autor), Annette Köster (Autor), Jürgen Hescheler (Autor), Konrad Brockmeier (Autor), Gerardus Bennink (Autor), Tobias Hannes (Autor)
• Format: Knjiga
• Izdano: Hindawi Limited, 2019-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Aims. Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) have become a promising tool in cardiovascular safety pharmacology. Immaturity of iPS-CMs remains an ongoing concern. We compared electrophysiological and contractile features of cardiac bodies (hiPS-CBs) derived from human-induced...