Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators
RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the global cancer burden. As a well-recognized target...
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Elsevier,
2021-11-01T00:00:00Z.
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