Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

• Main Authors: Yuran Qiu (Author), Yuanhao Wang (Author), Zongtao Chai (Author), Duan Ni (Author), Xinyi Li (Author), Jun Pu (Author), Jie Chen (Author), Jian Zhang (Author), Shaoyong Lu (Author), Chuan Lv (Author), Mingfei Ji (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the global cancer burden. As a well-recognized target...