Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

• Главные авторы: Tobias Fromme (Автор), Karin Kleigrewe (Автор), Andreas Dunkel (Автор), Angelika Retzler (Автор), Yongguo Li (Автор), Stefanie Maurer (Автор), Natascha Fischer (Автор), Rolf Diezko (Автор), Timo Kanzleiter (Автор), Verena Hirschberg (Автор), Thomas Hofmann (Автор), Martin Klingenspor (Автор)
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• Опубликовано: Elsevier, 2018-02-01T00:00:00Z.
• Предметы: article
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Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....