Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

• Main Authors: Tobias Fromme (Author), Karin Kleigrewe (Author), Andreas Dunkel (Author), Angelika Retzler (Author), Yongguo Li (Author), Stefanie Maurer (Author), Natascha Fischer (Author), Rolf Diezko (Author), Timo Kanzleiter (Author), Verena Hirschberg (Author), Thomas Hofmann (Author), Martin Klingenspor (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition....