Au@109Pd core-shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

• Main Authors: Nasrin Abbasi Gharibkandi (Author), Kamil Wawrowicz (Author), Agnieszka Majkowska-Pilip (Author), Kinga Żelechowska-Matysiak (Author), Mateusz Wierzbicki (Author), Aleksander Bilewicz (Author)
• Format: Book
• Published: SpringerOpen, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2 = 13.7 h) in th...