Au@109Pd core-shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

• Prif Awduron: Nasrin Abbasi Gharibkandi (Awdur), Kamil Wawrowicz (Awdur), Agnieszka Majkowska-Pilip (Awdur), Kinga Żelechowska-Matysiak (Awdur), Mateusz Wierzbicki (Awdur), Aleksander Bilewicz (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: SpringerOpen, 2023-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Background In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2 = 13.7 h) in th...