Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

• Главные авторы: Meijia Yang (Автор), Heng Wei (Автор), Yuelong Wang (Автор), Jiaojiao Deng (Автор), Yani Tang (Автор), Liangxue Zhou (Автор), Gang Guo (Автор), Aiping Tong (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2017-09-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...