Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

• প্রধান লেখক: Meijia Yang (লেখক), Heng Wei (লেখক), Yuelong Wang (লেখক), Jiaojiao Deng (লেখক), Yani Tang (লেখক), Liangxue Zhou (লেখক), Gang Guo (লেখক), Aiping Tong (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2017-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...