Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

• Main Authors: Catarina Chaves (Author), Xavier Declèves (Author), Meryam Taghi (Author), Marie-Claude Menet (Author), Joelle Lacombe (Author), Pascale Varlet (Author), Nagore G. Olaciregui (Author), Angel M. Carcaboso (Author), Salvatore Cisternino (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain cancer mortality lacking effective drug therapy. Using sham and DIPG-bearing rats, we analyzed (1) the brain distributi...