Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

• Автори: Catarina Chaves (Автор), Xavier Declèves (Автор), Meryam Taghi (Автор), Marie-Claude Menet (Автор), Joelle Lacombe (Автор), Pascale Varlet (Автор), Nagore G. Olaciregui (Автор), Angel M. Carcaboso (Автор), Salvatore Cisternino (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The blood-brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain cancer mortality lacking effective drug therapy. Using sham and DIPG-bearing rats, we analyzed (1) the brain distributi...