Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis

• Main Authors: Jeffrey T. Guptill (Author), John W. Sleasman (Author), Sophie Steeland (Author), Magdalena Sips (Author), Deborah Gelinas (Author), Hans de Haard (Author), Antoine Azar (Author), Kevin L. Winthrop (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antagonism of the neonatal Fc receptor (FcRn) by efgartigimod has been studied in several autoimmune diseases mediated by immunoglobulin G (IgG) as a therapeutic approach to remove pathogenic IgGs. Whereas reduction of pathogenic titres has demonstrated efficacy in multiple autoimmune diseases, redu...