Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

• Hoofdauteurs: Ashlee J. Conway (Auteur), Fiona C. Brown (Auteur), Elinor J. Hortle (Auteur), Gaetan Burgio (Auteur), Simon J. Foote (Auteur), Craig J. Morton (Auteur), Stephen M. Jane (Auteur), David J. Curtis (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2018-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this study, we performed a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate erythropoiesis. Here, we describe a recessive mouse strain, called RBC19, harbouring a point mutation within the housekeeping gene, Tpi1, which encodes th...