Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

• मुख्य लेखकों: Ashlee J. Conway (लेखक), Fiona C. Brown (लेखक), Elinor J. Hortle (लेखक), Gaetan Burgio (लेखक), Simon J. Foote (लेखक), Craig J. Morton (लेखक), Stephen M. Jane (लेखक), David J. Curtis (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2018-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In this study, we performed a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate erythropoiesis. Here, we describe a recessive mouse strain, called RBC19, harbouring a point mutation within the housekeeping gene, Tpi1, which encodes th...