In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism

• Main Authors: Igor Petkovic (Author), Nikolaus Bresgen (Author), Ettore Gilardoni (Author), Luca Regazzoni (Author), Koji Uchida (Author), Giancarlo Aldini (Author), Werner Siems (Author), Peter Eckl (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evidence suggests that the increased production of free radicals and reactive oxygen species lead to cellular aging. One of the consequences is lipid peroxidation generating reactive aldehydic products, such as 4-hydroxynonenal (HNE) that modify proteins and form adducts with DNA bases. To prevent d...