In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism

• मुख्य लेखकों: Igor Petkovic (लेखक), Nikolaus Bresgen (लेखक), Ettore Gilardoni (लेखक), Luca Regazzoni (लेखक), Koji Uchida (लेखक), Giancarlo Aldini (लेखक), Werner Siems (लेखक), Peter Eckl (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Evidence suggests that the increased production of free radicals and reactive oxygen species lead to cellular aging. One of the consequences is lipid peroxidation generating reactive aldehydic products, such as 4-hydroxynonenal (HNE) that modify proteins and form adducts with DNA bases. To prevent d...