An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo

• Main Authors: Janina Behrens (Author), Ingke Braren (Author), Michelle Y. Jaeckstein (Author), Luka Lilie (Author), Markus Heine (Author), Finnja Sass (Author), Judith Sommer (Author), Dagmar Silbert-Wagner (Author), Marceline M. Fuh (Author), Anna Worthmann (Author), Leon Straub (Author), Tarek Moustafa (Author), Joerg Heeren (Author), Ludger Scheja (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the sustained expression of proteins in vivo and have been successfully used for mechanistic studies in mice. A major challenge associated with this method is to obtain tissue specificity and high expression levels w...