A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients

• Κύριοι συγγραφείς: Ling Pei (Συγγραφέας), Run Li (Συγγραφέας), Hong Zhou (Συγγραφέας), Wenxin Du (Συγγραφέας), Yajie Gu (Συγγραφέας), Yingshuo Jiang (Συγγραφέας), Yongqing Wang (Συγγραφέας), Xin Chen (Συγγραφέας), Jianguo Sun (Συγγραφέας), Junrong Zhu (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2023-11-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic index and wide pharmacokinetic (PK) variability. We aimed to establish a physiologically based pharmacokinetic (PBPK) model of...