A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients

• Egile Nagusiak: Ling Pei (Egilea), Run Li (Egilea), Hong Zhou (Egilea), Wenxin Du (Egilea), Yajie Gu (Egilea), Yingshuo Jiang (Egilea), Yongqing Wang (Egilea), Xin Chen (Egilea), Jianguo Sun (Egilea), Junrong Zhu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic index and wide pharmacokinetic (PK) variability. We aimed to establish a physiologically based pharmacokinetic (PBPK) model of...