A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients

• Main Authors: Ling Pei (Author), Run Li (Author), Hong Zhou (Author), Wenxin Du (Author), Yajie Gu (Author), Yingshuo Jiang (Author), Yongqing Wang (Author), Xin Chen (Author), Jianguo Sun (Author), Junrong Zhu (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic index and wide pharmacokinetic (PK) variability. We aimed to establish a physiologically based pharmacokinetic (PBPK) model of...