Disulfiram Inclusion Complexes - A Nebulization Approach to Fight COVID-19

• Main Authors: Ana Maria Pereira (Author), Ayse Kaya (Author), Dan Alves (Author), Niusha Ansari-Fard (Author), Mohammad Najlah (Author)
• Format: Book
• Published: University of Huddersfield Press, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disulfiram (DS) has an excellent anti-viral activity; however, its low water-solubility and first-pass metabolism are limiting its clinical applications. Cyclodextrins (CDs) have been used as solubility enhancers and carriers of DS proposed for inhalation to treat SARS-CoV-19. Two types of CDs (hydr...