The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

• Автори: Aleksandrs Pustenko (Автор), Alessio Nocentini (Автор), Paola Gratteri (Автор), Alessandro Bonardi (Автор), Igor Vozny (Автор), Raivis Žalubovskis (Автор), Claudiu T. Supuran (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with KIs of 260 and 57 nM, r...