The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with KIs of 260 and 57 nM, r...

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Main Authors: Aleksandrs Pustenko (Author), Alessio Nocentini (Author), Paola Gratteri (Author), Alessandro Bonardi (Author), Igor Vozny (Author), Raivis Žalubovskis (Author), Claudiu T. Supuran (Author)
Format: Book
Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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