CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse

• Autori principali: Xiao-Rui Luan (Autore), Xiao-Ling Chen (Autore), Yue-Xiao Tang (Autore), Jin-Yan Zhang (Autore), Xiang Gao (Autore), Hai-Ping Ke (Autore), Zhao-Yu Lin (Autore), Xian-Ning Zhang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2018-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly specific genome-editing tool that has been used to treat monogenetic disorders. Epidermolytic palmoplantar keratoderma (EPPK) is a common autosomal dominant keratin disease resulting from dominant-negative mutation...