CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse

• Asıl Yazarlar: Xiao-Rui Luan (Yazar), Xiao-Ling Chen (Yazar), Yue-Xiao Tang (Yazar), Jin-Yan Zhang (Yazar), Xiang Gao (Yazar), Hai-Ping Ke (Yazar), Zhao-Yu Lin (Yazar), Xian-Ning Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2018-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly specific genome-editing tool that has been used to treat monogenetic disorders. Epidermolytic palmoplantar keratoderma (EPPK) is a common autosomal dominant keratin disease resulting from dominant-negative mutation...