Radiation-based immunogenic vaccine combined with a macrophage "checkpoint inhibitor" for boosting innate and adaptive immunity against metastatic colon cancers

• Príomhchruthaitheoirí: Hongbo Xu (Údar), Xianya Qin (Údar), Yuanyuan Guo (Údar), Siyu Zhao (Údar), Xingxing Feng (Údar), Runzan Zhang (Údar), Tianyi Tian (Údar), Li Kong (Údar), Conglian Yang (Údar), Zhiping Zhang (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2024-05-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic tumors. Especially, X-ray- induced dying tumor cells are rich in highly immunogenic tumor-associated antigens and self-generated dsDNA as potent adjuvants. Howe...