Radiation-based immunogenic vaccine combined with a macrophage "checkpoint inhibitor" for boosting innate and adaptive immunity against metastatic colon cancers

• Main Authors: Hongbo Xu (Author), Xianya Qin (Author), Yuanyuan Guo (Author), Siyu Zhao (Author), Xingxing Feng (Author), Runzan Zhang (Author), Tianyi Tian (Author), Li Kong (Author), Conglian Yang (Author), Zhiping Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic tumors. Especially, X-ray- induced dying tumor cells are rich in highly immunogenic tumor-associated antigens and self-generated dsDNA as potent adjuvants. Howe...