Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

Sulphamate and sulphamide derivatives have been largely investigated as carbonic anhydrase inhibitors (CAIs) by means of different experimental techniques. However, the structural determinants responsible for their different binding mode to the enzyme active site were not clearly defined so far. In...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Giuseppina De Simone (Tekijä), Emma Langella (Tekijä), Davide Esposito (Tekijä), Claudiu T. Supuran (Tekijä), Simona Maria Monti (Tekijä), Jean-Yves Winum (Tekijä), Vincenzo Alterio (Tekijä)
Aineistotyyppi: Kirja
Julkaistu: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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