Combining pharmacometric models with predictive and prognostic biomarkers for precision therapy in Crohn's disease: A case study of brazikumab

• Main Authors: Nan Zhang (Author), Ming Liang Chan (Author), Jing Li (Author), Philip Z. Brohawn (Author), Bo Sun (Author), Inna Vainshtein (Author), Lorin K. Roskos (Author), Raffaella Faggioni (Author), Rada M. Savic (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pharmacometric models were used to investigate the utility of biomarkers in predicting the efficacy (Crohn's Disease Activity Index [CDAI]) of brazikumab and provide a data‐driven framework for precision therapy for Crohn's disease (CD). In a phase IIa trial in patients with moder...