Combining pharmacometric models with predictive and prognostic biomarkers for precision therapy in Crohn's disease: A case study of brazikumab

• Главные авторы: Nan Zhang (Автор), Ming Liang Chan (Автор), Jing Li (Автор), Philip Z. Brohawn (Автор), Bo Sun (Автор), Inna Vainshtein (Автор), Lorin K. Roskos (Автор), Raffaella Faggioni (Автор), Rada M. Savic (Автор)
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• Опубликовано: Wiley, 2023-12-01T00:00:00Z.
• Предметы: article
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Abstract Pharmacometric models were used to investigate the utility of biomarkers in predicting the efficacy (Crohn's Disease Activity Index [CDAI]) of brazikumab and provide a data‐driven framework for precision therapy for Crohn's disease (CD). In a phase IIa trial in patients with moder...