Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...

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Main Authors: Elena Gabriele (Author), Chiara Ricci (Author), Fiorella Meneghetti (Author), Nicola Ferri (Author), Akira Asai (Author), Anna Sparatore (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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