Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

• Κύριοι συγγραφείς: Elena Gabriele (Συγγραφέας), Chiara Ricci (Συγγραφέας), Fiorella Meneghetti (Συγγραφέας), Nicola Ferri (Συγγραφέας), Akira Asai (Συγγραφέας), Anna Sparatore (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...