Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

• मुख्य लेखकों: Elena Gabriele (लेखक), Chiara Ricci (लेखक), Fiorella Meneghetti (लेखक), Nicola Ferri (लेखक), Akira Asai (लेखक), Anna Sparatore (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...