Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts

• Main Authors: Rangarajan Sambathkumar (Author), Eric Kalo (Author), Rob Van Rossom (Author), Marijke M. Faas (Author), Paul de Vos (Author), Catherine M. Verfaillie (Author)
• 格式: 图书
• 出版: Hindawi Limited, 2016-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Reprogramming can occur by the introduction of key transcription factors (TFs) as well as by epigenetic changes. We demonstrated that histone deacetylase inhibitor (HDACi) Trichostatin A (TSA) combined with a chromatin remodeling medium (CRM) induced expression of a number of definitive endoderm and...