Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats

• Main Authors: Wenxiu Lai (Author), Yulin Mo (Author), Dongtao Wang (Author), Ying Zhong (Author), Lujiao Lu (Author), Jiajia Wang (Author), Liao Cui (Author), Yanzhi Liu (Author), Yajun Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determi...