Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

• Main Authors: Nigel Bush (Author), Andrew Healey (Author), Anant Shah (Author), Gary Box (Author), Vladimir Kirkin (Author), Spiros Kotopoulis (Author), Svein Kvåle (Author), Per Christian Sontum (Author), Jeffrey Bamber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Acoustic Cluster Therapy (ACT) comprises coadministration of a formulation containing microbubble-microdroplet clusters (PS101) together with a regular medicinal drug and local ultrasound (US) insonation of the targeted pathological tissue. PS101 is confined to the vascular compartment...