Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest

• Main Authors: Zhongyuan Yao (Author), Jun Zeng (Author), Huimin Zhu (Author), Jing Zhao (Author), Xiaoxia Wang (Author), Qiuping Xia (Author), Yanping Li (Author), Lingqian Wu (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oocyte maturation arrest at metaphase I leads to fertilization failure in humans. In early embryos, the tubulin beta 8 class VIII (TUBB8) encodes a β-tubulin isotype and aids in the assembling of the human oocyte spindle. Mutations in the TUBB8 potentially interfere with human oo...