Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action.

• Auteurs principaux: Fernanda Fonseca-Silva (Auteur), Job D F Inacio (Auteur), Marilene M Canto-Cavalheiro (Auteur), Rubem F S Menna-Barreto (Auteur), Elmo E Almeida-Amaral (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The treatment for leishmaniasis is currently based on pentavalent antimonials and amphotericin B; however, these drugs result in numerous adverse side effects. The lack of affordable therapy has necessitated the urgent development of new drugs that are efficacious, safe, and more accessible to patie...