Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling-A Contribution from the ConcePTION Project

• Autores principales: Nina Nauwelaerts (Autor), Julia Macente (Autor), Neel Deferm (Autor), Rodolfo Hernandes Bonan (Autor), Miao-Chan Huang (Autor), Martje Van Neste (Autor), David Bibi (Autor), Justine Badee (Autor), Frederico S. Martins (Autor), Anne Smits (Autor), Karel Allegaert (Autor), Thomas Bouillon (Autor), Pieter Annaert (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacokinetic (PBPK) model to predict concentrations in h...