Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling-A Contribution from the ConcePTION Project

• Main Authors: Nina Nauwelaerts (Author), Julia Macente (Author), Neel Deferm (Author), Rodolfo Hernandes Bonan (Author), Miao-Chan Huang (Author), Martje Van Neste (Author), David Bibi (Author), Justine Badee (Author), Frederico S. Martins (Author), Anne Smits (Author), Karel Allegaert (Author), Thomas Bouillon (Author), Pieter Annaert (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacokinetic (PBPK) model to predict concentrations in h...