Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go-Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation

• Main Authors: Tomoko Sakaguchi (Author), Hideki Itoh (Author), Wei-Guang Ding (Author), Keiko Tsuji (Author), Iori Nagaoka (Author), Yuko Oka (Author), Takashi Ashihara (Author), Makoto Ito (Author), Yoshihiro Yumoto (Author), Naoko Zenda (Author), Yukei Higashi (Author), Youichi Takeyama (Author), Hiroshi Matsuura (Author), Minoru Horie (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

QT prolongation, a risk factor for arrhythmias, can result from genetic variants in one (or more) of the genes governing cardiac repolarization as well as intake of drugs known to affect a cardiac K+ channel encoded by human ether-a-go-go-related gene (HERG). In this paper, we will report a case of...