Intradermal delivery of vaccines: potential benefits and current challenges

• Main Authors: JK Hickling (Author), KR Jones (Author), M Friede (Author), D Zehrung (Author), D Chen (Author), D Kristensen (Author)
• Format: Book
• Published: The World Health Organization, 2011-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Delivery of vaccine antigens to the dermis and/or epidermis of human skin (i.e. intradermal delivery) might be more efficient than injection into the muscle or subcutaneous tissue, thereby reducing the volumes of antigen. This is known as dose-sparing and has been demonstrated in clinical trials wit...