Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes

• Main Authors: Qing Ling (Author), Lei Shen (Author), Wei Zhang (Author), DuoDuo Qu (Author), Hongdong Wang (Author), Bin Wang (Author), Yong Liu (Author), Jing Lu (Author), Dalong Zhu (Author), Yan Bi (Author)
• Formato: Libro
• Publicado: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Background Although type 1 diabetes (T1D) is typically described as a T cell-mediated autoimmune disease, increasing evidence for a role of B cells has emerged. However, the pivotal disease-relevant B cell subset and its contribution to islet autoimmunity remain elusive. Methods The frequen...