High-Mobility Group Box-1 Induces Decreased Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Retina

• Main Authors: Ahmed M. Abu El-Asrar (Author), Mohd Imtiaz Nawaz (Author), Mohammad Mairaj Siddiquei (Author), Abdullah S. Al-Kharashi (Author), Dustan Kangave (Author), Ghulam Mohammad (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To test the hypothesis that brain-derived neurotrophic factor-(BDNF-) mediated neuroprotection is reduced by high-mobility group box-1 (HMGB1) in diabetic retina, paired vitreous and serum samples from 46 proliferative diabetic retinopathy and 34 nondiabetic patients were assayed for BDNF, HMGB1, so...