Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

• Główni autorzy: Tarek S. Ibrahim (Autor), Mohamed M. Hawwas (Autor), Azizah M. Malebari (Autor), Ehab S. Taher (Autor), Abdelsattar M. Omar (Autor), Thikryat Neamatallah (Autor), Zakaria K. Abdel-Samii (Autor), Martin K. Safo (Autor), Yaseen A. M. M. Elshaier (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A new series of quinoline derivatives of combretastatin A-4 have been designed, synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds showed significant antiproliferative activities, among them, 12c exhibited the most potent inhibitory activity against different ca...