Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

• Main Authors: Tarek S. Ibrahim (Author), Mohamed M. Hawwas (Author), Azizah M. Malebari (Author), Ehab S. Taher (Author), Abdelsattar M. Omar (Author), Thikryat Neamatallah (Author), Zakaria K. Abdel-Samii (Author), Martin K. Safo (Author), Yaseen A. M. M. Elshaier (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of quinoline derivatives of combretastatin A-4 have been designed, synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds showed significant antiproliferative activities, among them, 12c exhibited the most potent inhibitory activity against different ca...