Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

• Main Authors: Wei Sun (Author), Ruochen Liu (Author), Xinyue Gao (Author), Zini Lin (Author), Hongao Tang (Author), Hongjuan Cui (Author), Erhu Zhao (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis. The SGOC pathway is a crucial metabolic network in tumorigenesis, wherein the outputs are required...