Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

• Hoofdauteurs: Wei Sun (Auteur), Ruochen Liu (Auteur), Xinyue Gao (Auteur), Zini Lin (Auteur), Hongao Tang (Auteur), Hongjuan Cui (Auteur), Erhu Zhao (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2023-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis. The SGOC pathway is a crucial metabolic network in tumorigenesis, wherein the outputs are required...