Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension

• 主要な著者: Andreas Becker (著者), Axel Krebs‐Brown (著者), Claudia Vetter (著者), Tanja Reuter (著者), Almudena Rodriguez‐Gutierrez (著者), Xiaoli You (著者), Michael Lissy (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Peposertib is an orally administered inhibitor of DNA‐dependent protein kinase. We evaluated the effect of food on its pharmacokinetics, and examined the pharmacokinetics of an oral suspension (OS) of disintegrated tablets, in a phase I, open‐label, crossover three‐period study (NCT04702698...